About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:

Non-small Cell Lung Cancer (NSCLC)

HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

Job Title: Sr. Medical Science Liaison

Location: Oxford, UK or Zug, Switzerland or Dublin, Ireland

Overview of Role:

The Associate Director, Clinical Supply Management supports the Senior Director in leading the full scope of global clinical supply chain responsibilities. The role translates functional strategy into disciplined execution across demand and supply planning, inventory management, packaging and labelling, distribution, returns and destruction, cross-border compliance, and GxP operations. Acting as a key delegate for the Senior Director, the (Associate) Director provides a layer of management for direct reports, establishes clear priorities and performance expectations, develops team capability, and drives operational excellence through standardized processes, meaningful metrics, proactive risk management, and continuous improvement. The role partners closely with Clinical Operations, Commercial, CMC, Quality, Regulatory, Finance, Legal, Procurement, Medical Affairs and Program Management, and oversees external partners including Contract Development and Manufacturing Organizations (CDMOs), IXRS providers and specialist service providers.

Role and Responsibilities:

Supports the Senior Director in developing functional strategy, operating plans, budgets, governance and performance objectives across global clinical supply chain activities
Leads day-to-day execution for new and ongoing studies and products, ensuring robust forecasting, supply planning, schedule adherence, inventory optimization, global logistics and sustained GxP compliance
Serves as a delegate for the Senior Director in cross-functional forums, governance meetings, supplier reviews and issue escalation, providing clear recommendations and ensuring timely follow-through.
Manages and develops direct reports, translating functional priorities into individual objectives, balancing workloads, coaching performance, supporting career development and ensuring appropriate succession and capability plans.
Creates an effective management layer by coordinating team activities, reinforcing accountability, removing operational barriers and escalating material risks or decisions to the Senior Director.
Overseeing the Clinical Supply Management (CSM) team, the Associate Director interprets complex clinical protocols, development plans and commercial demand forecasts, working with CMC and internal and external partners to develop packaging, labelling, supply and resupply strategies, timelines and plans.
Supports the accountability of CSM team to oversee packaging, labelling, release, distribution, resupply, returns, reconciliation and destruction activities across global locations
Develops and maintains supply project budgets, resource plans and integrated schedules, monitors performance and proactively resolves variances
Manages CDMO and service-provider activities from RFP and contracting support through routine operations, troubleshooting, invoicing and performance management using defined KPIs and service expectations
Supports IXRS selection, design, set-up, User Acceptance Testing (UAT), implementation and ongoing operational performance as required by IRT Management Team.
Drives operational excellence by defining standard work, governance routines, KPIs and dashboards; uses trend and root-cause analysis to improve service, quality, cost, compliance and team productivity
Leads continuous-improvement initiatives that streamline and harmonize processes, strengthen inspection readiness and embed sustainable ways of working
Supports regulatory submissions, audits and inspections and ensures timely management of SOPs, change controls, deviations, investigations and CAPAs within the function
Provides continuity of leadership and performs other responsibilities within the function as assigned

Experience, Education and Specialized Knowledge and Skills:

BSc, MSc, engineering or pharmacy degree, or equivalent, with a minimum of 8+ years of progressive supply chain experience in a pharmaceutical, biotechnology or contract development and manufacturing organization (CDMO) environment
Demonstrated success leading complex international clinical studies and product supply chains, with broad knowledge of regulatory and GMP requirements for IMP and commercial product packaging and supply
Prior people-management experience, including setting objectives, coaching performance, developing talent, delegating effectively and managing through others
Demonstrated ability to translate strategy into executable priorities, operating rhythms, metrics and measurable team outcomes
Strong operational-excellence and continuous-improvement capability, including process standardization, KPI management, root-cause analysis and sustainable implementation of improvements
Solid understanding of IXRS design specifications, set-up and UAT, together with proficiency in clinical supply planning and forecasting tools
Strong project, budget, risk and resource-management skills, with the ability to manage multiple priorities while maintaining high-quality results
Expertise in outsourcing, supplier governance, negotiation and performance management
Experience building, scaling or improving end-to-end product supply chains and associated business processes
Ability to operate as a trusted